Grants

Lab Director Grants

• Active

  The Role of Iron in Pulmonary Fibrosis

  2022-2026, National Institutes of Health/NHLBI, R01HL157450, $1,878,032

   

  The Role of Iron in Pulmonary Fibrosis

  2023-2026, National Institutes of Health/NHLBI, R01HL157450A1S1, $182,528

   

  The Role of FENDRR in Host Defense Against Mycobacterium Tuberculosis Infection

  2022 - 2027, National Institutes of Health/NIAID, R01AI173180, $2,963,619 (Contact PI, Yong Cheng, MPI, Lin Liu)

   

  Genome-wide Screening for Host LncRNAs Regulating Host Defense against Mycobacterial Infection in Macrophages

  2022 - 2024, National Institutes of Health/NIAID, R21AI166118, $$411,400 (Contact PI, Yong Cheng, MPI, Lin Liu)

   

  Lnc-PINK Regulation of Innate Immunity in Lung Epithelial Cells (influenza virus)

  2021 - 2024, National Institutes of Health/NIAID, R21AI152004, $$411,400

   

  Role of Tankryase 2 in Lung Innate Immunity (influenza virus)

  2020 - 2023, Oklahoma Center for the Advancement of Science and Technology, HR20-050, $135,000

   

  Oklahoma Center for Respiratory and Infectious Diseases (CoBRE, Center of Biomedical Research Excellence)

  2013 - 2018, National Institutes of Health/NIGMS, P20GM103648, $11,231,206

   

  miR-101 Control of Pulmonary Fibrosis

  2013 - 2018, National Institutes of Health/NHLBI, R01HL116876, $1,434,655

   

  Oklahoma Center for Respiratory and Infectious Diseases (Phase II CoBRE, Center of Biomedical Research Excellence)

  2018 - 2024, National Institutes of Health/NIGMS, P20GM103648, $11,118,648

   

  Oklahoma Center for Respiratory and Infectious Diseases (Phase III CoBRE, Center of Biomedical Research Excellence)

  2023 - 2028, National Institutes of Health/NIGMS, P30GM149368, $5,535,001

• Completed

  An iPSC-derived Human Lung Tissue Model for Post-Acute Sequelae of SARS-CoV-2 Infection

  2022-2022, Oklahoma Center for Adult Stem Cell Research, $168,000

   

  Development of a COVID-19 Human Lung Tissue Model for Drug Screen using iPSCs

  2021-2021, Oklahoma Center for Adult Stem Cell Research, $168,000

   

  Iron and Lung Toxicity

  2021-2022, CVM, Oklahoma State University, $10,000.

   

  Modeling Influenza Virus Infection Using iPSC-derived Alveolar Organoids

  2020, Oklahoma Center for Adult Stem Cell Research, $168,000

   

  CRISPRa LncRNA Screen for the Differentiation of Mesenchymal Stem Cells into Alveolar Epithelial Type II Cells

  2019, Oklahoma Center for Adult Stem Cell Research, $168,000

   

  Acquiring NanoSight NS 300 for Adult Stem Cell Research

  2018, Oklahoma Center for Adult Stem Cell Research, $75,013

   

  The Role of LncRNAs in Pulmonary Fibrosis

  2017-2023, National Institutes of Health/NHLBI, R01HL135152, $1,496,000

   

  MicroRNA-193b regulation of influenza virus replication

  2016 - 2020, National Institutes of Health/NIAID, R21AI121591, $402,325

   

  Stem cell-based therapy of influenza virus infection

  2016 - 2017, Oklahoma Center for Adult Stem Cell Research, $168,000

   

  RNA_seq analysis of α7 nicotinic acetylcholine receptor activated lung epithelial cells

  2016-2017, CVHS, Oklahoma State University, $11,640.

   

  Mesenchymal Stem Cell Exosomes for Treating COPD

  2015 - 2016, Oklahoma Center for Adult Stem Cell Research, $168,000

   

  Purinergic P2X7 Receptor as a Pro-inflammatory Molecule

  2014 - 2017, Oklahoma Center for the Advancement of Science and Technology, Oklahoma Health Research Grant, HR14-060, $135,000

   

  Mesenchymal stem cell-derived lung epithelial cells for COPD therapy

  2014 - 2015, Oklahoma Center for Adult Stem Cell Research, $168,000

   

  Oklahoma Center for Respiratory and Infectious Diseases (Phase I CoBRE, Center of Biomedical Research Excellence)

  2013 - 2018, National Institutes of Health/NIGMS, P20GM103648, $11,231,206

   

  miR-101 Control of Pulmonary Fibrosis

  2013 - 2019, National Institutes of Health/NHLBI, R01HL116876, $1,434,655

   

  Interdisciplinary Program in Regenerative Medicine at OSU

  2013 - 2014, OSU Planning Grants for Establishing Creative Interdisciplinary Programs, $34,900

   

  Regulation of Influenza Virus Replication

  2013 - 2014, Research Advisory Committee, CVHS, Oklahoma State University, $15,000

   

  MicroRNA Technology

  2012 - 2014, Technology Business Development Program (TBDP), Oklahoma State University, $20,000

   

  MicroRNA-mediated Differentiation of Induced Pluripotent Stem Cells into Alveolar Epithelial Type II cells: Mechanisms and Therapy for COPD

  2012 - 2013, Oklahoma Center for Adult Stem Cell Research, Oklahoma Center for Adult Stem Cell Research, $112,000

   

  A Shared Equipment for Creating a Lung Disease Model to Test Efficacy of Adult Stem Cell Therapy

  2012, Oklahoma Center for Adult Stem Cell Research, $42,560

   

  Regulation of VAMP-2 in Alveolar Type II Cells by MicroRNA-206

  2011 - 2013, American Heart Association, South Central Affiliate, #11GRNT7450069, $140,000

   

  Cell-based Therapy of COPD Using Induced Pluripotent Stem Cell-Derived Alveolar Epithelial Type II cells

  2011 - 2012, Oklahoma Center for Adult Stem Cell Research, $72,800 

   

  Development of MicroRNA Expression Library

  2010 - 2012, Oklahoma Center for the Advancement of Science and Technology, Oklahoma Applied Research Support (AR101.1-037), $90,000

   

  Reprogramming of Adult Lung Cells for Cell-Based Therapy

  2010-2011, Oklahoma Center for Adult Stem Cell Research, $72,800 

   

  Purchase of Shared Equipment for Testing Efficacy of Adult Stem Cell Therapy

  2010 - 2011, Oklahoma Center for Adult Stem Cell Research, $62,638 

   

  Paracine Regulation of Lung Surfactant Secretion

  2010-2011, Research Advisory Committee, Center for Veterinary Health Sciences, OSU, $15,000

   

  MicroRNAs and Bovine Respiratory Disease

  2009 - 2012, U.S. Department of Agriculture 2009-035505-05855, $225,000

   

  Role of MicroRNAs in Bronchopulmonary Dysplasia

  2009 - 2011, National Institutes of Health/NHLBI, R21 HL087884, $402,600

   

  MicroRNA Expression Profiling in Idiopathic Pulmonary Fibrosis

  2009 - 2011, National Institutes of Health/NHLBI R03 HL095383, $147,700

   

  Molecular Signaling in Alveolar Epithelial Cells

  2009, Research Advisory Committee, Center for Veterinary Health Sciences, OSU, $20,000

   

  Role of MicroRNAs in Bronchopulmonary Dysplasia

  2008 - 2009, Oklahoma Center for the Advancement of Science and Technology, Oklahoma Health Research Grant, HR08-064, $45,000

   

  Mechanisms of Alveolar Fluid Transport

  2006 - 2010, National Institutes of Health/NHLBI, R01 HL083188, $1,423,125

   

  Biotechnology, Gene Silencing using RNA Interference

  2006 - 2007, Technology and Business Assessment Group (TBAG), Oklahoma State University, $30,000

   

  GABA Receptor and Pulmonary Fluid Transport

  2005 - 2008, March of Dimes Birth Defects, 6FY-05-76, $258,075

   

  Molecular Mechanisms of Lung Surfactant Secretion

  2004 - 2008, National Institutes of Health/NHLBI R01, HL-052146, $1,214,400

   

  Mechanisms of Alveolar Epithelial Cell Differentiation

  2003 - 2007, National Institutes of Health/NHLBI, R01 HL-071628, $1,214,400

   

  Postdoctoral Research Supplements for Underrepresented Minorities (Marcia Davita Howard)

  2002 - 2004, National Institutes of Health/NHLBI, R01 HL-52146S1, $116,148

   

  Lung Epithelial Cell Differentiation and Oxidative Stress

  2002 - 2004, American Heart Association, Heartland Affiliate, Grant-in-Aid, 0255992Z, $110,000

   

  Arsenic-induced Changes of Gene Expression in Lung cells

  2002 - 2003, Centers for Disease Control and Prevention, $20,000

   

  Regulation of Lung Surfactant Secretion by Nitric Oxide

  2001 - 2004, Oklahoma Center for the Advancement of Science and Technology, Oklahoma Health Research Grant, HR01-093, $135,000

   

  Regulation of Bovine Annexin II by Phosphorylation

  2001 - 2003, Oklahoma Agricultural Experiment Station, $ 43,695

   

  Molecular Mechanisms of Lung Surfactant Secretion

  2000 - 2004, National Institutes of Health/NHLBI, R01 HL-52146, $922,829

   

  Graduate Research Assistants with Disabilities Supplement (William H. Rowan)

  1998 - 2002, National Institutes of Health/NHLBI, R01 HL-52146S, $141,696

   

  Annexins and Lung Surfactant Secretion

  1995 - 2000, National Institutes of Health/NHLBI, R29, 1.0 percentile, R01 HL-52146, $485,772

Lab Member Grants

• 2004-2022

  Zhu, Mechanisms of IFIT-mediated Suppression of Influenza Virus Infection

  2021-2022, Research Advisory Committee, College of Veterinary Medicine, Oklahoma State University, $3,000

   

  Hewawasam, Role of GPX4 in Lung Macrophages in Pulmonary Fibrosis

  2021-2022, Research Advisory Committee, College of Veterinary Medicine, Oklahoma State University, $3,000

   

  Dang, Iron Accumulation in lung Fibroblasts through Slc39a8 Transporter

  2021-2022, Research Advisory Committee, College of Veterinary Medicine, Oklahoma State University, $3,000

   

  Munteanu, Role of Exosomes Derived from Ferroptotic Lung Epithelial Cells in Lung Fibrosis

  2020-2021, Research Advisory Committee, College of Veterinary Medicine, Oklahoma State University, $3,000

   

  Huang, Expression Profiles of Long Noncoding RNAs in Lungs Infected by SARS-CoV-2 Virus

  2020-2021, Research Advisory Committee, College of Veterinary Medicine, Oklahoma State University, $10,000

   

  Bamunuarachchi, Tankyrase Regulation of Influenza Virus Replication

  2019-2020, Research Advisory Committee, College of Veterinary Medicine, Oklahoma State University, $3,000

   

  Zhu, PARP 9 and 14 Regulation of Influenza Virus Infection

  2019-2020, Research Advisory Committee, College of Veterinary Medicine, Oklahoma State University, $3,000

   

  Vaddadi, Identification of LncRNAs that Protect against Influenza Virus Infection using a CRISPR Activation Screen

  2019-2020, Research Advisory Committee, College of Veterinary Medicine, Oklahoma State University, $3,000

   

  Sivasami, Human Induced Pluripotent Stem Cells Derived Lung Organoids for Influenza Infection Model

  2019-2020, Research Advisory Committee, College of Veterinary Medicine, Oklahoma State University, $3,000

   

  Chaoqun Huang, LncRNA FENDRR Control of Idiopathic Pulmonary Fibrosis

  2017-2018, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $15,000

   

  Lakmini Senavirathna, Hypoxia and TGF-β Regulation of Long Noncoding RNA FENDRR in Human Pulmonary Fibroblasts

  2017-2018, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $3,000

   

  Gayan Bamunuarachchi, MicroRNA-206 Regulation of Influenza Virus Replication

  2017-2018, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $3,000

   

  Samuel Jeyasingh, Regulation of Influenza A Virus Infection by a Novel Cellular LncRNA, lnc-PINK1-2

  2017-2018, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $3,000

   

  Sunil More, Inhibition of influenza A virus infection by cellular MicroRNA

  2015 - 2016, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $3,000 

   

  Yujie Guo, Tankyrase-targeted miRNAs in Regulation of Influenza Virus Infection

  2014 - 2015, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $5,000

   

  Xuxu Gou, Role of human mesenchymal stem cell-derived microvesicles in the repair of cigarette smoking extract-induced injury of alveolar epithelial type II cells

  2014 - 2015, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $3,000

   

  Lakmini Kumari Senavirathna, Hypoxia regulation of miR-101 in pulmonary cells

  2014 - 2015, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $3,000

   

  Li Zhang, miRNA-modified mouse mesenchymal stem cells and COPD

  2014- 2015, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $3,000

   

  Xiao Xiao, Regulation of the Differentiation of Fibroblasts to Myofibroblasts during EMT by miR-424

  2012 - 2015, American Heart Association, Southwest Affiliate, predoctoral fellowship, #12PRE12060188, $50,000

   

  Sunil More, The Role of Wnt/β-catenin in Influenza A Virus Infection

  2013- 2014, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $3,000

   

  Chaoqun Huang, Identification of Functional MicroRNA-mRNA Pairs in Rat ARDS

  2013 - 2014, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $15,000

   

  Yujie Guo, An Important Function of Platelet-derived DKK1 in the Progression of Acute Lung Injury

  2012 - 2013, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $3,000

   

  Li Zhang, MicroRNA Regulation of the Derivation of Alveolar Type II cells from Mouse Induced Pluripotent Stem Cells

  2012 - 2013, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $3,000

   

  Xiao Xiao, Role of EZH2 and Its Inhibitor DZNep in Idiopathic Pulmonary Fibrosis

  2012 - 2013, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $2,200

   

  Sunil More, Role of Autophagy in Bronchopulmonary Dysplasia

  2011 - 2012, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $3,000

   

  Eyayu Kefyyalew Belay, Generation of Induced Pluripotent Stem Cell Derived Alveolar Epithelial Type II Cells for the Cell Therapy of Lung Diseases

  2011 - 2012, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $4,832

   

  Amarjit Mishra, The Novel Function of sVCAM-1 in ARDS patients

  2011 - 2012, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $3,000

   

  Dhananjay Shukla, Role of miR-150 and Its Target, GPNMB on the Pathogenesis of Bronchopulmonary Dysplasia

  2011 - 2012, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $6,000

   

  Yang Wang, miR-124a Regulates Fetal Alveolar Epithelial Maturation

  2011 - 2012, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $3,000

   

  Xiao Xiao, The Functions of miRNAs in the Regulation of EMT

  2011 - 2012, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $3,000

   

  Yujie Guo, Activation of Wnt/beta-catenin Signaling Inhibits Inflammation during Acute Lung Injury

  2011 - 2012, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $3,000

   

  Li Zhang, microRNA Profiling in Bovine Alveolar Macrophage

  2011 - 2012, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $3,000

   

  Yujie Guo, The Role of P2X7R-mediated Purinergic Signaling in Alveolar Epithelial Cell Death

  2009-2011, American Heart Association, South Central Affiliate, predoctoral fellowship #09PRE2300211, $50,000

   

  Amarjit Mishra, Role of R2X7 Receptor in Acute Lung Injury

  2010, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $3,000

   

  Narendranath Reddy Chintagari, Role of GABA Receptors in Fetal Lung Development

  2010, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $7,000

   

  Chaoqun Huang, Regulation of miR-124 by WNT/beta-catenin Signaling

  2010, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $6,000

   

  Dong Xi, Crosstalk of miR-21 and TGF-B/BMP Signaling Pathway in Bronchopulmonary Dysplasia

  2010, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $6,000

   

  Deming Gou, miR-20a-mediate Anti-apoptosis by Up-regulating Survivin via E2F3

  2008 – 2010, American Heart Association, South Central Affiliate, Beginning Grant-in-Aid, $140,000

   

  Yang Wang, miRNA Regulation of the Wnt/beta-catenin Pathway during the Trans-differentiation of Alveolar Epithelial Cells

  2008 - 2009, American Heart Association, Midwest Affiliate, predoctoral fellowship, 08100016Z, $50,000

   

  Yujie Guo, Prolonged Activation of P2X7R Leads to Alveolar Epithelial Type I Cell Death by Suppressing Wnt/beta-catenin Pathway,

  2009, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $3,000

   

  Yang Wang, Role of miR-375 in Fetal Lung Development by In Utero Gene Delivery

  2009, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $3,000

   

  Chuanxiu Yang, The Mechanisms of UTP Regulation of Alveolar Fluid Transport

  2008 - 2009, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $10,000

   

  Tingting Weng, Functional Study of Pleiotrophin during Fetal Lung Development using Knockout mice

  2008 - 2009, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $3,000

   

  Amarjit Mishra, Purinergic P2X7 receptor: Alveolar Type I and Type II cell Communications

  2008 - 2009, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $3,000

   

  Lijing Su, Ionotropic GABA Receptors in AT1 Contribute to Fluid Clearance in Alveoli

  2008 - 2009, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $3,000

   

  Honghao Zhang, Identification of miRNA Involved in Regulation of Surfactant Secretion

  2007 - 2008, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $7,000

   

  Deming Gou, Functional Interactions between ANX2 and Its Associated Proteins: Rab 14 and Id1

  2007 - 2008, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $10,000

   

  Tingting Weng, Functional studies of PTN in fetal lung development

  2006 - 2007, American Heart Association, Heartland Affiliate, predoctoral fellowship, 0610143Z, $50,000

   

  Narendranath Reddy Chintagari, Proteomic Analysis of Lipid Rafts Isolated from Alveolar Type II Cells

  2006 - 2007, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $5,000

   

  Pengcheng Wang, Identification of Proteins in Lamellar Bodies Involving in Lung Surfactant Secretion

  2006 - 2007, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $5,000

   

  Manoj Bhaskaran, Trans-differentiation of Alveolar Type II Epithelial Cells to Type I: Role of TGF β1 pathway

  2005 - 2006, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $5,000

   

  Yang Wang, Functions of miRNAs in Fetal Lung Developmen

  2005 - 2006, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $5,000

   

  Letitia Posey, Arsenic, Cancer, and Animal Health and Welfare

  2006, Morris Animal Foundation, Veterinary Student fellowship, $4,000

   

  Zhongming Chen, Quantitative DNA Microarray: Application in Cardiopulmonary Diseases

  2003 - 2005, American Heart Association, Heartland Affiliate, predoctoral fellowship, 0315260Z, $42,000

   

  Nili Jin, Differential Expression of GABA Receptor in Cultured Alveolar Type II Cells

  2003 - 2005, American Heart Association, Heartland Affiliate, predoctoral fellowship, 0315256Z, $42,000

   

  Tingting Weng, Gene Profiling of Rat Fetal Lung Development using 10K DNA Microarray

  2004- 2005, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $5,000

   

  Narendranath Reddy Chintagari, Lipid Rafts: Implications for Surfactant Secretion by Alveolar Type II Cells

  2004 - 2005, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $2,500

   

  Deming Gou, Identify Annexin A2-regulated Genes by RNAi and cDNA Microarray

  2004 - 2005, Research Advisory Committee, Center for Veterinary Health Sciences, Oklahoma State University, $20,000