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Oklahoma State University

Neurotoxicology Laboratory

The above video shows an Interdisciplinary project to develop a nano-scavenger.

Research Areas

  • Age-related sensitivity to pesticides
  • Endocannabinoid signaling in neurotoxicity and neuroprotection
  • Enzyme-based bioscavengers against OP intoxication
  • Non-cholinesterase targets of anticholinesterases

Affiliations

Environmental Health Sciences Review Committee, National Institute of Environmental Health Sciences, Durham, NC

Research Advisory Committee on Gulf War Veterans’ Illnesses, U.S. Department of Veterans Affairs, Washington, DC

Academy of Toxicological Sciences, Raleigh, NC

Society of Toxicology

International Neurotoxicology Association

Current Projects

CBPR on Pesticide Exposure and Neurological Outcomes for Latinos: PACE5”, RO1 ES008739-20, NIEHS 9/1/2017-8/31/2022.

Modulating protein dynamics to enhance butyrylcholinesterase-mediated ghrelin metabolism, OSU 5-150060”, 11/1/2020-10/30-2021.

Recent Publications

  1. Singh MP, Flynn, NH, Sethuraman SN, Liu J, Ramsey JD, Pope C, Ranjan A. (2021). Reprogramming the rapid clearance of thrombolytics by nanoparticle encapsulation and anchoring to circulating red blood cells. J Control Rel. 329: 148-161.

  2. Liu J, Hester K, Pope C. (2020). Dose- and time-related effects of acute diisopropylfluorophosphate intoxication on forced swim behavior and sucrose preference in rats. NeuroToxicology 82:82-88.

  3. Hester K, Bhattari K, Jiang H, Agarwal P, Pope C. (2019). Engineering dynamic surface peptide networks on butyrylcholinesteraseG117H for enhanced organophosphate catalysis. Chem Res Toxicol. 32:1801-1810.

  4. Anderson T, Liu J, McMurry S, Pope C. (2018). Comparative in vitro and in vivo effects of chlorpyrifos oxon in the outbred mouse (Mus musculus) and Great Plains toad (Anaxyrus cognatus). Environ Toxicol Chem. 37: 1898-1906.

  5. Pope CN, Brimijoin S. (2018). Cholinesterases and the fine line between poison and remedy. Biochem Pharmacol. 153:205-216. (Invited review in 60th Jubilee edition).

  6. Hester K, Liu J, Flynn N, Sultatos LG, Geng L, Brimijoin S, Ramsey JD, Hartson S, Ranjan A, Pope C. (2017). Polyionic complexes of butyrylcholinesterase and poly-l-lysine-g-poly(ethylene glycol): Comparative kinetics of catalysis and inhibition and in vitro inactivation by proteases and heat. Chem Biol Interact. 275: 86-94.

  7. Bahrami M, Laurienti PJ, Quandt SA, Talton J, Pope CN,  Summers P, Burdette JH, Chen H, Liu J, Howard TD, Arcury TA, Simpson SL. (2017). The Impacts of Pesticide and Nicotine Exposures on Latino Farmworkers’ Functional Brain Networks. NeuroToxicology 62: 138-150.

  8. Sahoo K,  Karumuri S,  Hikkaduwa Koralege R, Flynn N, Hartson S, Liu J, Ramsey J, Kalkan K, Pope C, Ranjan A. (2017). Molecular and biocompatibility characterization of red blood cell membrane targeted and cell penetrating peptide-modified polymeric nanoparticles. Mol. Pharmaceut. 14: 2224-2235.

  9. Bhawadraj M, Katz SD, Pope CN and Maxwell LK. (2017). Subacute pyridostigmine exposure increases heart rate recovery and cardiac parasympathetic tone in rats. Clin Exper Pharmacol Physiol 44: 872-879.

Members

Dr. Carey Pope, PI

Kirstin Hester, PhD. Postdoctoral associate

Debarati Chanda, MS, Ph.D candidate

Alex Benton, BS, undergraduate researcher