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Oklahoma State University

Research Focus

HIFU directed image guided chemo-immunotherapy

  1. Our research shows that HIFU hyperthermia can achieve tumor-directed dose escalations from Low Temperature-Sensitive Liposomes (LTSL). To improve HIFU guided image-guided therapy of deep-seated tumors (e.g. colon and liver tumors), we are investigating ultrasound contrast agent loaded LTSLs for determining time-resolved absolute tumor temperature and reporting of solid tumor drug penetration (Fig.1).
  2. We are combining HIFU, imageable liposomes and in-situ vaccines to understand the mechanism of abscopal effect and immunotherapy in rodent and dog melanomas (Fig.2).
  3. Acute and chronic non-healing wounds can lead to adverse outcomes including amputation. Our research is focused on using LTSLs and HIFU to enhance delivery of antimicrobial agents, improve antimicrobial sensitivity and provide therapy with real-time non-invasive control (Fig. 3).

Nanoparticle half-life enhancement and therapy of hypoxic tumor core

Recent findings suggest that PEGylation of drug/nanoparticles (NPs) can induce an immune response following repeated injection, and this has been shown to decrease tissue-specific drug delivery and targeting. To prolong drug half-life and targeting of hypoxic core, we are developing red blood cell and attenuated bacterial strains attached nanoparticles for solid tumor targeting and thromboprophylactic applications.

Hyperthermia/Nanoparticle mediated proton therapy

There is a critical need to better localize and target chemo-radio therapy at the treatment site. We are combining proton irradiation with hyperthermia and nanoparticle to achieve immunomodulation and improve site-directed therapy.

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Fig. 1

 

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Fig. 2

 

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Fig. 3

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 Fig. 4